YBR038W

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Systematic name YBR038W
Gene name CHS2
Aliases
Feature type ORF, Verified
Coordinates Chr II:311898..314789
Primary SGDID S000000242


Description of YBR038W: Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]





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References

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  1. Cid VJ, et al. (1995) Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae. Microbiol Rev 59(3):345-86 SGD PMID 7565410
  2. Schmidt M, et al. (2002) In budding yeast, contraction of the actomyosin ring and formation of the primary septum at cytokinesis depend on each other. J Cell Sci 115(Pt 2):293-302 SGD PMID 11839781
  3. Shaw JA, et al. (1991) The function of chitin synthases 2 and 3 in the Saccharomyces cerevisiae cell cycle. J Cell Biol 114(1):111-23 SGD PMID 2050738
  4. Teh EM, et al. (2009) Retention of Chs2p in the ER requires N-terminal CDK1-phosphorylation sites. Cell Cycle 8(18):2964-74 SGD PMID 19713768
  5. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  6. submitted by Jeff Ubersax on 2004-01-21

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