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Systematic name YBR037C
Gene name SCO1
Aliases PET161
Feature type ORF, Verified
Coordinates Chr II:311452..310565
Primary SGDID S000000241

Description of YBR037C: Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins[1][2][3]


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Protein Details

Other Protein Details

Other Topic: Regulated by the diauxic shift (glycerol)

Apart form the overall increase in mitochondrial protein mass after the diauxic shift this protein remains unchanged after the diauxic shift. [4] [5]



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  1. Balatri E, et al. (2003) Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assembly. Structure 11(11):1431-43 SGD PMID 14604533
  2. Nittis T, et al. (2001) Yeast Sco1, a protein essential for cytochrome c oxidase function is a Cu(I)-binding protein. J Biol Chem 276(45):42520-6 SGD PMID 11546815
  3. Rentzsch A, et al. (1999) Mitochondrial copper metabolism in yeast: mutational analysis of Sco1p involved in the biogenesis of cytochrome c oxidase. Curr Genet 35(2):103-8 SGD PMID 10079328
  4. Ohlmeier S, et al. (2004) The yeast mitochondrial proteome, a study of fermentative and respiratory growth. J Biol Chem 279(6):3956-79 SGD PMID 14597615
  5. submitted by Steffen Ohlmeier on 2004-04-08

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