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Systematic name YBR034C
Gene name HMT1
Aliases HCP1, ODP1, RMT1
Feature type ORF, Verified
Coordinates Chr II:305976..304930
Primary SGDID S000000238

Description of YBR034C: Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p[1][2][3][4][5][6]


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  1. Chen YC, et al. (2010) Protein Arginine Methylation Facilitates Cotranscriptional Recruitment of Pre-mRNA Splicing Factors. Mol Cell Biol 30(21):5245-56 SGD PMID 20823272
  2. Gary JD, et al. (1996) The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. J Biol Chem 271(21):12585-94 SGD PMID 8647869
  3. Henry MF and Silver PA (1996) A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins. Mol Cell Biol 16(7):3668-78 SGD PMID 8668183
  4. Lipson RS, et al. (2010) Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae. Biochem Biophys Res Commun 391(4):1658-62 SGD PMID 20035717
  5. Shen EC, et al. (1998) Arginine methylation facilitates the nuclear export of hnRNP proteins. Genes Dev 12(5):679-91 SGD PMID 9499403
  6. Wong CM, et al. (2010) Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p. Nucleic Acids Res 38(7):2217-28 SGD PMID 20053728

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