Difference between revisions of "YBR017C"

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'''Description of YBR017C:''' Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression<ref name='S000072260'>Asakawa K and Toh-e A (2002) A defect of Kap104 alleviates the requirement of mitotic exit network gene functions in Saccharomyces cerevisiae. Genetics 162(4):1545-56 {{SGDpaper|S000072260}} PMID 12524331</ref><ref name='S000052126'>Seedorf M and Silver PA (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5 {{SGDpaper|S000052126}} PMID 9238021</ref><ref name='S000049555'>Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 {{SGDpaper|S000049555}} PMID 8849456</ref><ref name='S000042377'>Lee DC and Aitchison JD (1999) Kap104p-mediated nuclear import. Nuclear localization signals in mRNA-binding proteins and the role of Ran and Rna. J Biol Chem 274(41):29031-7
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'''Description of YBR017C:''' Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis<ref name='S000129312'>van den Bogaart G, et al. (2009) Nuclear transport factor directs localization of protein synthesis during mitosis. Nat Cell Biol {{SGDpaper|S000129312}} PMID 19198597</ref><ref name='S000052126'>Seedorf M and Silver PA (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5 {{SGDpaper|S000052126}} PMID 9238021</ref><ref name='S000049555'>Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 {{SGDpaper|S000049555}} PMID 8849456</ref><ref name='S000042377'>Lee DC and Aitchison JD (1999) Kap104p-mediated nuclear import. Nuclear localization signals in mRNA-binding proteins and the role of Ran and Rna. J Biol Chem 274(41):29031-7
 
  {{SGDpaper|S000042377}} PMID 10506153</ref>
 
  {{SGDpaper|S000042377}} PMID 10506153</ref>
 
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Revision as of 07:21, 26 February 2009

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Systematic name YBR017C
Gene name KAP104
Aliases
Feature type ORF, Verified
Coordinates Chr II:273703..270947
Primary SGDID S000000221


Description of YBR017C: Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis[1][2][3][4]




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References

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  1. van den Bogaart G, et al. (2009) Nuclear transport factor directs localization of protein synthesis during mitosis. Nat Cell Biol SGD PMID 19198597
  2. Seedorf M and Silver PA (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5 SGD PMID 9238021
  3. Aitchison JD, et al. (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7 SGD PMID 8849456
  4. Lee DC and Aitchison JD (1999) Kap104p-mediated nuclear import. Nuclear localization signals in mRNA-binding proteins and the role of Ran and Rna. J Biol Chem 274(41):29031-7 SGD PMID 10506153

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