Difference between revisions of "YBR008C"
SGDwikiBot (talk | contribs) (Automated import of articles) |
SGDwikiBot (talk | contribs) (Automated import of articles) |
||
| Line 18: | Line 18: | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of YBR008C:''' Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs<ref name='S000042127'>Broco N, et al. (1999) FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on pdr3 transcriptional regulator. Yeast 15(15):1595-608 {{SGDpaper|S000042127}} PMID 10572257</ref><ref name='S000044268'>Jungwirth H, et al. (2000) Diazaborine resistance in yeast involves the efflux pumps Ycf1p and Flr1p and is enhanced by a gain-of-function allele of gene YAP1. Eur J Biochem 267(15):4809-16 {{SGDpaper|S000044268}} PMID 10903515</ref><ref name='S000052308'>Alarco AM, et al. (1997) AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J Biol Chem 272(31):19304-13 | + | '''Description of YBR008C:''' Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin<ref name='S000042127'>Broco N, et al. (1999) FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on pdr3 transcriptional regulator. Yeast 15(15):1595-608 {{SGDpaper|S000042127}} PMID 10572257</ref><ref name='S000044268'>Jungwirth H, et al. (2000) Diazaborine resistance in yeast involves the efflux pumps Ycf1p and Flr1p and is enhanced by a gain-of-function allele of gene YAP1. Eur J Biochem 267(15):4809-16 {{SGDpaper|S000044268}} PMID 10903515</ref><ref name='S000052308'>Alarco AM, et al. (1997) AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J Biol Chem 272(31):19304-13 {{SGDpaper|S000052308}} PMID 9235926</ref><ref name='S000114597'>Iwahashi Y, et al. (2006) Mechanisms of patulin toxicity under conditions that inhibit yeast growth. J Agric Food Chem 54(5):1936-42 |
| − | {{SGDpaper| | + | {{SGDpaper|S000114597}} PMID 16506856</ref> |
<br> | <br> | ||
<br> | <br> | ||
Revision as of 14:05, 30 April 2009
Share your knowledge...Edit this entry! <protect>
| Systematic name | YBR008C |
| Gene name | FLR1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:254210..252564 |
| Primary SGDID | S000000212 |
Description of YBR008C: Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin[1][2][3][4]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
DNA and RNA Details
Other DNA and RNA Details
Other Topic: expression
Specifically higher expression in sulfur limited chemostat cultures versus sulfur excess. [5] [6]
<protect>
References
See Help:References on how to add references
- ↑ Broco N, et al. (1999) FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on pdr3 transcriptional regulator. Yeast 15(15):1595-608 SGD PMID 10572257
- ↑ Jungwirth H, et al. (2000) Diazaborine resistance in yeast involves the efflux pumps Ycf1p and Flr1p and is enhanced by a gain-of-function allele of gene YAP1. Eur J Biochem 267(15):4809-16 SGD PMID 10903515
- ↑ Alarco AM, et al. (1997) AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. J Biol Chem 272(31):19304-13 SGD PMID 9235926
- ↑ Iwahashi Y, et al. (2006) Mechanisms of patulin toxicity under conditions that inhibit yeast growth. J Agric Food Chem 54(5):1936-42 SGD PMID 16506856
- ↑ Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
- ↑ submitted by Viktor Boer on 2003-07-25
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
