Difference between revisions of "YBL088C"
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| − | '''Description of YBL088C:''' Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)<ref name='S000070073'>Craven RJ, et al. (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161(2):493-507 {{SGDpaper|S000070073}} PMID 12072449</ref><ref name='S000071732'>Giannattasio M, et al. (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002 {{SGDpaper|S000071732}} PMID 12271137</ref><ref name='S000072773'>Nakada D, et al. (2003) The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 31(6):1715-24 {{SGDpaper|S000072773}} PMID 12626713</ref><ref name='S000040194'>Ritchie KB and Petes TD (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-9 | + | '''Description of YBL088C:''' Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)<ref name='S000070073'>Craven RJ, et al. (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161(2):493-507 {{SGDpaper|S000070073}} PMID 12072449</ref><ref name='S000071732'>Giannattasio M, et al. (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002 {{SGDpaper|S000071732}} PMID 12271137</ref><ref name='S000072773'>Nakada D, et al. (2003) The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 31(6):1715-24 {{SGDpaper|S000072773}} PMID 12626713</ref><ref name='S000040194'>Ritchie KB and Petes TD (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-9 {{SGDpaper|S000040194}} PMID 10790418</ref><ref name='S000150401'>Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () |
| − | {{SGDpaper| | + | {{SGDpaper|S000150401}} PMID 22842922</ref> |
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Latest revision as of 14:05, 16 August 2012
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| Systematic name | YBL088C |
| Gene name | TEL1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:59382..51019 |
| Primary SGDID | S000000184 |
Description of YBL088C: Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)[1][2][3][4][5]
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References
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- ↑ Craven RJ, et al. (2002) Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes. Genetics 161(2):493-507 SGD PMID 12072449
- ↑ Giannattasio M, et al. (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002 SGD PMID 12271137
- ↑ Nakada D, et al. (2003) The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res 31(6):1715-24 SGD PMID 12626713
- ↑ Ritchie KB and Petes TD (2000) The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics 155(1):475-9 SGD PMID 10790418
- ↑ Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
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