From SGD-Wiki
Revision as of 07:45, 23 January 2012 by SGDwikiBot (talk | contribs) (Automated import of articles)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YBL020W
Gene name RFT1
Feature type ORF, Verified
Coordinates Chr II:182401..184125
Primary SGDID S000000116

Description of YBL020W: Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein[1][2][3][4][5]


Community Commentary

About Community Commentary. Please share your knowledge!



See Help:References on how to add references

  1. Frank CG, et al. (2008) Does Rft1 flip an N-glycan lipid precursor? Nature 454(7204):E3-4; discussion E4-5 SGD PMID 18668045
  2. Helenius J, et al. (2002) Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415(6870):447-50 SGD PMID 11807558
  3. Koerte A, et al. (1995) Suppression of the yeast mutation rft1-1 by human p53. J Biol Chem 270(38):22556-64 SGD PMID 7673248
  4. Rush JS, et al. (2009) Suppression of Rft1 Expression Does Not Impair the Transbilayer Movement of Man5GlcNAc2-P-P-Dolichol in Sealed Microsomes from Yeast. J Biol Chem 284(30):19835-42 SGD PMID 19494107
  5. Sanyal S, et al. (2008) Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Biochemistry 47(30):7937-46 SGD PMID 18597486

See Help:Categories on how to add the wiki page for this gene to a Category </protect>