Difference between revisions of "YBL020W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YBL020W YBL020W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000116 YBL020W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RFT1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RFT1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr II:182404..184128
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|nowrap| Chr II:182401..184125
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000116
 
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'''Description of {{PAGENAME}}:''' Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein<ref name='S000069444'>Helenius J, et al. (2002) Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415(6870):447-50 {{SGDpaper|S000069444}} PMID 11807558</ref><ref name='S000046279'>Koerte A, et al. (1995) Suppression of the yeast mutation rft1-1 by human p53. J Biol Chem 270(38):22556-64
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'''Description of YBL020W:''' Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein<ref name='S000127251'>Frank CG, et al. (2008) Does Rft1 flip an N-glycan lipid precursor? Nature 454(7204):E3-4; discussion E4-5 {{SGDpaper|S000127251}} PMID 18668045</ref><ref name='S000069444'>Helenius J, et al. (2002) Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415(6870):447-50 {{SGDpaper|S000069444}} PMID 11807558</ref><ref name='S000046279'>Koerte A, et al. (1995) Suppression of the yeast mutation rft1-1 by human p53. J Biol Chem 270(38):22556-64 {{SGDpaper|S000046279}} PMID 7673248</ref><ref name='S000130527'>Rush JS, et al. (2009) Suppression of Rft1 Expression Does Not Impair the Transbilayer Movement of Man5GlcNAc2-P-P-Dolichol in Sealed Microsomes from Yeast. J Biol Chem 284(30):19835-42 {{SGDpaper|S000130527}} PMID 19494107</ref><ref name='S000126850'>Sanyal S, et al. (2008) Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Biochemistry 47(30):7937-46
  {{SGDpaper|S000046279}} PMID 7673248</ref>
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  {{SGDpaper|S000126850}} PMID 18597486</ref>
 
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==Community Commentary==
 
==Community Commentary==
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YBL020W
Gene name RFT1
Aliases
Feature type ORF, Verified
Coordinates Chr II:182401..184125
Primary SGDID S000000116


Description of YBL020W: Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein[1][2][3][4][5]




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Community Commentary

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References

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  1. Frank CG, et al. (2008) Does Rft1 flip an N-glycan lipid precursor? Nature 454(7204):E3-4; discussion E4-5 SGD PMID 18668045
  2. Helenius J, et al. (2002) Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415(6870):447-50 SGD PMID 11807558
  3. Koerte A, et al. (1995) Suppression of the yeast mutation rft1-1 by human p53. J Biol Chem 270(38):22556-64 SGD PMID 7673248
  4. Rush JS, et al. (2009) Suppression of Rft1 Expression Does Not Impair the Transbilayer Movement of Man5GlcNAc2-P-P-Dolichol in Sealed Microsomes from Yeast. J Biol Chem 284(30):19835-42 SGD PMID 19494107
  5. Sanyal S, et al. (2008) Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Biochemistry 47(30):7937-46 SGD PMID 18597486

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