YAL056W

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Systematic name YAL056W
Gene name GPB2
Aliases KRH1
Feature type ORF, Verified
Coordinates Chr I:39260..41902
Primary SGDID S000000052


Description of YAL056W: Regulator of cAMP-PKA signaling that functions downstream of Gpa2p and Cyr1p to directly inhibit protein kinase A, increasing its cAMP dependancy; regulated directly by the G-alpha protein Gpa2p; kelch-repeat containing Gpb1p homolog[1][2][3][4][5]




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References

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  1. Niranjan T, et al. (2007) Kelch Repeat Protein Interacts with the Yeast G{alpha} Subunit Gpa2p at a Site That Couples Receptor Binding to Guanine Nucleotide Exchange. J Biol Chem 282(33):24231-8 SGD PMID 17584745
  2. Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9 SGD PMID 16924114
  3. Lu A and Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins. Eukaryot Cell 4(11):1794-800 SGD PMID 16278446
  4. Batlle M, et al. (2003) Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J Cell Sci 116(Pt 4):701-10 SGD PMID 12538771
  5. Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 SGD PMID 12150916

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