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Systematic name YAL039C
Gene name CYC3
Feature type ORF, Verified
Coordinates Chr I:69526..68717
Primary SGDID S000000037

Description of YAL039C: Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)[1][2]


Community Commentary

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Anti-sense transcription on the Watson Strand opposite CYC3 has been observed in the absences of RRP6 and XRN1.



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  1. Dumont ME, et al. (1991) Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol 11(11):5487-96 SGD PMID 1656231
  2. Dumont ME, et al. (1987) Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. EMBO J 6(1):235-41 SGD PMID 3034577

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