YAL026C

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Systematic name YAL026C
Gene name DRS2
Aliases FUN38, SWA3
Feature type ORF, Verified
Coordinates Chr I:99698..95631
Primary SGDID S000000024


Description of YAL026C: Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; localizes to the trans-Golgi network; contributes to clathrin-coated vesicle formation and endocytosis; type 4 P-type ATPase[1][2][3][4][5]




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References

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  1. Alder-Baerens N, et al. (2006) Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles. Mol Biol Cell 17(4):1632-42 SGD PMID 16452632
  2. Natarajan P, et al. (2004) Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function. Proc Natl Acad Sci U S A 101(29):10614-9 SGD PMID 15249668
  3. Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 SGD PMID 12631737
  4. Gall WE, et al. (2002) Drs2p-dependent formation of exocytic clathrin-coated vesicles in vivo. Curr Biol 12(18):1623-7 SGD PMID 12372257
  5. Chen CY, et al. (1999) Role for Drs2p, a P-type ATPase and potential aminophospholipid translocase, in yeast late Golgi function. J Cell Biol 147(6):1223-36 SGD PMID 10601336

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