Difference between revisions of "YAL019W"
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| − | '''Description of YAL019W:''' | + | '''Description of YAL019W:''' Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; involved in double-strand break (DSB) response; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies<ref name='S000132810'>Awad S, et al. (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84 {{SGDpaper|S000132810}} PMID 20075079</ref><ref name='S000040251'>Clark MW, et al. (1992) Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8(2):133-45 {{SGDpaper|S000040251}} PMID 1561836</ref><ref name='S000151022'>Costelloe T, et al. (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.LID - 10.1038/nature11353 [doi] Nature () {{SGDpaper|S000151022}} PMID 22960744</ref><ref name='S000151231'>Durand-Dubief M, et al. (2012) SWI/SNF-Like Chromatin Remodeling Factor Fun30 Supports Point Centromere Function in S. cerevisiae. PLoS Genet 8(9):e1002974 {{SGDpaper|S000151231}} PMID 23028372</ref><ref name='S000132432'>Neves-Costa A, et al. (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111 {{SGDpaper|S000132432}} PMID 19956593</ref><ref name='S000052609'>Ouspenski II, et al. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8 {{SGDpaper|S000052609}} PMID 10454593</ref><ref name='S000117178'>Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 {{SGDpaper|S000117178}} PMID 16823961</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 |
{{SGDpaper|S000074306}} PMID 14574415</ref> | {{SGDpaper|S000074306}} PMID 14574415</ref> | ||
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Latest revision as of 14:05, 17 October 2012
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| Systematic name | YAL019W |
| Gene name | FUN30 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr I:114919..118314 |
| Primary SGDID | S000000017 |
Description of YAL019W: Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; involved in double-strand break (DSB) response; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies[1][2][3][4][5][6][7][8]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [8] [9]
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References
See Help:References on how to add references
- ↑ Awad S, et al. (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84 SGD PMID 20075079
- ↑ Clark MW, et al. (1992) Identification of a Saccharomyces cerevisiae homolog of the SNF2 transcriptional regulator in the DNA sequence of an 8.6 kb region in the LTE1-CYS1 interval on the left arm of chromosome I. Yeast 8(2):133-45 SGD PMID 1561836
- ↑ Costelloe T, et al. (2012) The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.LID - 10.1038/nature11353 [doi] Nature () SGD PMID 22960744
- ↑ Durand-Dubief M, et al. (2012) SWI/SNF-Like Chromatin Remodeling Factor Fun30 Supports Point Centromere Function in S. cerevisiae. PLoS Genet 8(9):e1002974 SGD PMID 23028372
- ↑ Neves-Costa A, et al. (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111 SGD PMID 19956593
- ↑ Ouspenski II, et al. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8 SGD PMID 10454593
- ↑ Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961
- ↑ 8.0 8.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-21
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