Positions in yeast labs

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PhD project position in cell polarization and membrane biology - Martin lab (posted 22 August 2019)

Description: We use a target-based strategy based on surrogate genetics in yeast to discover and develop drug candidates directed against proteins from the Plasmodium malaria parasite previously unexplored as drug targets. Genes encoding conserved proteins likely to perform essential functions, from the Plasmodium malaria parasite, are cloned into vectors for regulatable expression in yeast. The human protein ortholog is expressed in a parallel yeast strain, and the effects of candidate drugs on growth of yeast strains expressing the parasite or the human protein are compared.

Position Overview: The successful PhD candidate should have an interest in participating in an interdisciplinary international project. Beside a molecular biology/microbiology background, proficiency in one or more of the following areas is valuable: bioinformatics, genomics, programming, high throughput techniques including robotics, biochemistry, molecular modelling, structural biology, and pharmacy.

How to apply: This PhD project at the University of Gothenburg, Sweden will soon open for applications. The starting date is flexible but has to be in 2020. We are looking for candidates with an interest in an international collaborative project and having a molecular biology background. Experience from yeast genetics is advantageous. Interested candidates can contact Per Sunnerhagen for more information.

Post-doctoral position in cell polarization and membrane biology - Martin lab (posted 22 August 2019)

Description: The Martin lab at the University of Lausanne, Switzerland, is looking for an outstanding, highly motivated candidate to study the process of cell-cell fusion. Cell-cell fusion is a critical process that underlies fertilization in all eukaryotic cells as well as the formation of many tissues in multicellular organisms. Research projects will aim to understand the mechanisms of cell polarization and membrane reorganization that happens during fusion. Candidates bringing expertise in proteomics, electron microscopy and/or quantitative imaging are particularly welcome to apply.

Position Overview: The candidate will hold a PhD thesis and a good publication record (at least one first-author publication in a reputable peer-reviewed journal). S/he will be highly motivated to excel in science, curious and open-minded. Strong background in cell and molecular biology is required. Prior research experience on yeast cell biology would be an asset, but is not essential. The lab is located on the joint UNIL-EPFL international research campus in Lausanne, 200m from lake Geneva, and has access to all state-of-the art equipment. Please visit our website for more information on our group, research interests and publications: http://www.unil.ch/martinlab.

How to apply: Please send your full application including motivation letter, CV, list of publications and the names and email addresses of 2-3 referees to Sophie Martin. The University of Lausanne offers at first a 1-year contract, which can be renewed for up to a maximum of 5 years; salary according to University of Lausanne pay scale.

Postdoctoral Position in Yeast Molecular Biology/Bioinformatics (posted 20 August 2019)

Description: A NIH-funded postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology, Immunology & Molecular Genetics at the University of Texas Health Science Center at San Antonio. Research will use cutting-edge techniques to study molecular mechanisms that control gene expression, morphology, virulence and virulence-related properties in response to host environmental cues in the yeast Candida albicans, a major human fungal pathogen. For additional details and previous publications, please see [1]. Many opportunities are available for collaboration with both basic and clinical fungal pathogenesis researchers at the large and internationally recognized San Antonio Center for Medical Mycology (see [2]). The successful applicant will receive equivalent to NIH-level salary and full benefits. Located in south central Texas, near both Austin and the Texas Hill Country, San Antonio is one of the lowest cost-of-living major metropolitan areas in the U.S.

Position Overview: Highly motivated individuals with previous experience and a strong track record in molecular biology, bioinformatics, genomics, cell biology, genetics, and/or protein chemistry are especially encouraged to apply. Bioinformatics/computational biology experience in any system is strongly preferred but not required. Prior experience in fungal pathogenesis is not necessarily required.

How to apply: Please send a cover letter outlining your research interests, CV, and contact information for three references to David Kadosh (kadosh@uthscsa.edu). All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.

Postdoctoral and technician positions – University of Rochester (posted 18 July 2019)

Description: A postdoctoral position and a technician position are available immediately in the Elena Rustchenko laboratory in University of Rochester, Rochester, NY, which studies the evolution of echinocandin drug resistance. Studies will focus on mechanisms that are responsible for the increased tolerance to echinocandin drugs subsequently leading to true resistance in Candida albicans.

Position Overview:Applicants should have a Ph.D. in an area related to molecular and cell biology, biochemistry or microbiology. Experience with C. albicans is preferred. We will also employ an experienced technician.

How to apply: Please, send a cover letter, a concise summary of previous research activities, a complete CV and contact information for referees to Elena Rustchenko, elena_bulgac@urmc.rochester.edu.

PhD and post-doctoral research positions - Prof. Martin Kupiec's lab at Tel Aviv University (posted 17 July 2019)

Description: We work with yeast (S. cerevisiae and S. pombe) exploring the role of Elg1 and other proteins in genome stability maintenance and telomere biology. Additional projects include exploring the interphase between DNA replication, chromatin modifications, sister-chromatid cohesion and DNA repair.

Position Overview: We are seeking highly motivated candidates with expertise in molecular biology and genetics. Experience in yeast genetics is desirable, but not a requirement. Independence, communication and interpersonal skills are valued in order to work in a young, dynamic, diverse, and collaborative environment. We are an international team, and research is carried out in English.

How to apply: Prospective candidates should submit a cover letter describing their research experience, scientific interest, career goals, and motivation to apply for this position. Please include an updated CV and the contact information of at least two references. Questions should be directed to Prof. Martin Kupiec at martin@tauex.tau.ac.il.

Postdoctoral Fellow - Garcia Lab at the University of Oregon (posted 26 April 2019)

Department Description: The Institute of Molecular Biology (IMB) is a research institute that has 18 labs and approximately 150 employees, including 45 graduate students who train in our labs. We have an administrative structure, which includes accounting, purchasing, personnel, PI support, building management, and three service centers, including genomics and cell characterization, and imaging.

Position Overview: The Postdoctoral Fellow will carry out studies of eukaryotic epigenetic regulation using mostly genetic, biochemical, and cell biological techniques in yeast and/or mammalian cells. The purpose is to make high-impact discoveries in the field of epigenetics. In particular, work will involve study of prion proteins (non-toxic) and their impact on RNA regulation, as well as how stress affects epigenetic mechanisms in cells. More info is available at garcialab.org.

How to apply: Please email Dr. Garcia. Include your CV (which includes three professional references) and a brief statement about your research interests (1/2 to 1 page).