Difference between revisions of "Positions in yeast labs"

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==’’’Post-doc Opening - quantitative genetics of drug resistance in Saccharomyces cerevisiae’’’==
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=='''Research Associate – Fermentation at Nucelis (posted 16 January 2019)'''==
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'''Description:'''  [https://www.nucelis.com Nucelis] is focused on delivering naturally sourced and sustainable solutions to the personal care, nutrition and flavor and fragrance markets. Nucelis’ business model is to work with partners to apply our Rapid Trait Development System RTDS™ a suite of proprietary, non-GMO precision gene editing technologies, coupled with extensive fermentation and downstream process development expertise to improve the economics of manufacture of microbial fermentation products.
  
Project Description
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'''Position Overview:''' Nucelis Inc. is looking for an experienced Fermentation Research Associate to join our fermentation process development team. This person will play a hands-on roll among operating our lab and pilot scale fermentations, collecting and processing samples, operating analytical equipment, preparing fermentation experiment documents, and participating in data analysis and process development/improvement discussions. The job will also include some general lab duties such as stocking/ ordering supplies, washing glassware and media preparation.  
A post-doc position is open in the laboratory of John McCusker (https://mgm.duke.edu/faculty-and-research/primary-faculty/john-h-mccusker-phd/) in the Department of Molecular Genetics & Microbiology at Duke University Medical Center on a newly funded R01 to work on the quantitative genetics of drug resistance in Saccharomyces cerevisiae. The post-doc position requires demonstrated productivity (i.e. publications) as well as expertise in genetics (preferably microbial, ideally with S. cerevisiae) and in molecular biology.  Please provide curriculum vitae, as well as the names and contact information for three references.
 
  
Applications must be made via Academic Jobs Online (https://academicjobsonline.org/ajo/jobs/9718).
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'''How to apply:''' Please check the website (https://www.nucelis.com/join-our-team.php) for the details.
  
Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual’s age, color, disability, genetic information, gender, gender identity, gender expression, national origin, race, religion, sexual orientation, or veteran status.
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=='''Senior Research Specialist or Scientist – Strain Development (1 position) at Nucelis (posted 16 January 2019)'''==
  
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[https://www.nucelis.com Nucelis] is a trait development company in San Diego, CA, focused on the construction of commercially useful strains of microorganisms is looking for a Senior Research Specialist or Scientist to assist the R&D team to develop microbial hosts for the production of metabolites.
  
=='''Postdoc Opening - Autophagy of lipid droplets in YEAST (posted 29 August 2017)'''==
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'''How to apply:''' Please check the website (https://www.nucelis.com/join-our-team.php) for the details.
  
'''Postdoctoral project:''' Autophagy of lipid droplets in YEAST
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=='''Systems Chemical Biologist at Yumanity Therapeutics (posted 7 December 2018)'''==
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'''Description:''' Yumanity Therapeutics (http://www.yumanity.com/) is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Even though an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.
  
::'''Academic institution:''' University of California, San Diego
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'''Position Overview:'''
::
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The systems chemical biologist will work as an integral part of the target identification team, which uses large-scale forward and reverse genetic approaches to reveal the cellular targets of compounds discovered from phenotypic screens. The position reports to the target identification team lead, and will interact across all Yumanity’s core platforms, including chemistry, yeast screening, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team.
::'''Academic division:''' Division of Biological Sciences
 
::
 
::'''Academic unit:''' Section of Molecular Biology
 
  
'''Description:''' Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy induction is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with experience (http://postdoc.ucsd.edu/appointment-guidelines/).
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For more information on this position, please visit the Yumanity careers page (http://www.yumanity.com/careers/). If you would like to apply, please submit your CV with the "Systems Chemical Biologist" in the subject line to [mailto:careers@yumanity.com careers@yumanity.com].
  
'''Applicant requirements:''' The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in YEAST genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells or zebrafish model is a plus but not essential. Preference will be given to candidates with experience in autophagy pathway or with LDs.
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=='''Postdoctoral Researcher or Research Scientist Position (1 position) in the Boone Team (RIKEN, Japan)  (posted 7 December 2018)'''==
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A Postdoctoral Researcher or Research Scientist position is available in Dr. Charles Boone’s laboratory at RIKEN (http://www.riken.jp/en/research/labs/csrs/mol_ligand_targ). We are seeking a highly motivated candidate with strong expertise in yeast genetics/molecular biology and human cell culture experiments. The candidate will develop innovative techniques based on genetic networks in yeast and human cells that leads to quick and accurate detection of the ligand-target interactions.  
  
'''How to apply:''' Please send your cover letter, CV and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu
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'''How to apply:''' Please check the website (http://www.riken.jp/en/careers/researchers/20181129_5/) for the details.
  
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=='''Postdoctoral Position in Yeast Molecular Biology (posted 5 September 2018)'''==
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A NIH-funded postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology, Immunology & Molecular Genetics at the University of Texas Health Science Center at San Antonio. Research will use cutting-edge techniques to study molecular mechanisms that control gene expression, morphology, virulence and virulence-related properties in response to host environmental cues in the yeast ''Candida albicans'', a major human fungal pathogen. For additional details and previous publications, please see https://wp.uthscsa.edu/mimg/team-member/david-kadosh-ph-d/.
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Highly motivated individuals with previous experience and a strong track record in molecular biology, genomics, cell biology, genetics, bioinformatics and/or protein chemistry are especially encouraged to apply. Previous experience in fungal pathogenesis is not necessarily required. Please send a cover letter outlining your research interests, CV, and contact information for three references to David Kadosh (kadosh@uthscsa.edu).
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Many opportunities are available for collaboration with both basic and clinical researchers at the large and internationally recognized San Antonio Center for Medical Mycology (see http://www.sacmm.org/).
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The successful applicant will receive equivalent to NIH-level salary and full benefits. Located in south central Texas, near both Austin and the Texas Hill Country, San Antonio is one of the lowest cost-of-living major metropolitan areas in the U.S.
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All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.
  
=='''Postdoc Position in Non-coding Transcription in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
 
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is seeking a postdoc commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is for 2 years with the possibility of extension.  A Hallas-Møller Investigator Award to Sebastian Marquardt funds the position.
 
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark.
 
  
Project description
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=='''The Kupiec lab is recruiting PhD students and post-docs (posted 2 July 2018)'''==
The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . We are looking for a postdoc to work on two lab focus areas within this field:
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'''Description''': PhD positions and post-doctoral research positions are available in Prof. Martin Kupiec’s laboratory at Tel Aviv University (https://mkyeastlab.wixsite.com/mklab). We work with yeast (''S. cerevisiae'' and ''S. pombe'') exploring the role of Elg1 and other proteins in genome stability maintenance and telomere biology. Additional projects include exploring the interphase between DNA replication, chromatin modifications, sister-chromatid cohesion and DNA repair.
 
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<br><br>
- Divergent lncRNA Transcription (1) <br>
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We are seeking highly motivated candidates with expertise in molecular biology and genetics. Experience in yeast genetics is desirable, but not a requirement. Independence, communication and interpersonal skills are valued in order to work in a young, dynamic, diverse, and collaborative environment. We are an international team, and research is carried out in English.
- Functional Consequences of Non-Coding Transcription (2, 3)<br>
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'''How to apply''': Prospective candidates should submit a '''cover letter''' describing their research experience, scientific interest, career goals, and motivation to apply for this position. Please include an '''updated CV''' and the contact information of '''at least two references'''. Questions should be directed to Prof. Martin Kupiec at martin@post.tau.ac.il.
The position builds on unpublished data of the lab. We have identified novel factors controlling transcription of non-coding sequences in budding yeast. You will determine the genome-wide effect of these factors by suitable cutting-edge transcriptomics techniques. You will help to elucidate the molecular mechanisms that are required for divergent non-coding transcription from gene promoters. We use the knowledge of molecular mechanisms to study the functional roles of non-coding transcription in yeast and plants.  
 
 
 
We are seeking an enthusiastic candidate familiar with high-throughput approaches, ideally with topically relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and application requirements:
 
 
 
http://jobportal.ku.dk/alle-opslag/?show=904563
 
 
 
Deadline: 15th June 2017.
 
 
 
(1) Marquardt et al. Cell. 2014
 
(2) Marquardt et al. Mol Cell. 2014
 
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors
 
 
 
=='''Ph.D. Fellow in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)''' ==
 
Project description
 
Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is offering a 3-year Ph.D.-fellowship commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is funded by a Hallas-Møller Investigator Award to Sebastian Marquardt.
 
http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark
 
 
 
The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . Our preliminary data support a Ph.D. position in any of these three focus areas within non-coding transcription research:
 
 
 
- Divergent lncRNA Transcription (1) <br>
 
- Functional Consequences of Non-Coding Transcription (2, 3) <br>
 
- Transcription Kinetics in Environmental Interactions (4) <br>
 
 
 
Please specify in your Cover Letter what attracts you for a Ph. D. in any of these focus areas. Our lab employs cutting edge budding yeast technology to identify the molecular mechanisms controlling transcription of non-coding sequences. The knowledge of non-coding transcription mechanisms helps us to study the functional roles of non-coding transcription. For example, we disrupt non-coding transcription in Arabidopsis to identify roles of non-coding transcription in plant environmental responses. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/
 
 
 
A successful candidate will be enthusiastic about the general research area, ideally with relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and requirements:
 
http://jobportal.ku.dk/alle-opslag/?show=904540
 
 
 
Deadline: 15th June 2017.
 
 
 
(1) Marquardt et al. Cell. 2014
 
(2) Marquardt et al. Mol Cell. 2014
 
(3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors
 
(4) Hazelbaker, Marquardt, et al. Mol Cell. 2013
 
 
 
=='''Postdoctoral position in synthetic biology. Montpellier, France. (posted january 20, 2017)''' ==
 
 
 
A post-doctoral position is available for 24 months at the “UMR-Sciences pour l’Œnologie de Montpellier” (UMR INRA 1083), in the Microbiology team, starting approximately in March 2017.
 
 
 
This work is part of a project financed by the “Agence Nationale de la Recherche” (ANR) (for details see ENZINVIVO project http://www.agence-nationale-recherche.fr/fileadmin/aap/2016/selection/aap-g-anr-DS10-selection-2016.pdf).
 
Enzyme reactions have long been analyzed in vitro, using pure enzymes and diluted buffer conditions. Due to the large amount of data generated and collected with thousands of enzymes, enzymology has made tremendous progress on understanding the incredible power of biocatalysts. However, dilute, in vitro conditions are far from the surroundings of natural enzymatic reactions that take place inside cells. The cellular medium is more accurately described as a heterogeneous crowded gel, dense and filled with all sorts of macromolecules and cellular lipidic organelles which may result in some partitioning effects and changes in diffusion. Therefore, enzymatic parameters determined using classical enzymology setups may not perfectly represent the real, in vivo based, rate and equilibrium constants. Although some advances have been made toward the comprehension of viscosity and crowding effects, we are still far to derive rate and equilibrium parameters from in vivo enzymatic reactions.
 
The project ENZINVIVO will address this issue focusing on two isoforms of phytoene synthase (carotenoid biosynthesis) as model enzymes. The enzymatic properties of these enzymes will be investigated in vitro, through a set of measurement in environments of increasing complexity and in vivo expressing the carotenoid biosynthesis pathway in S. cerevisiae and using synthetic biology tools and concepts to tune, at will, substrate and enzyme levels.
 
We aim at deciphering:
 
- how the intracellular medium influences enzymatic reactions.
 
- how can we build an in vivo approach to measure enzymatic parameters.
 
- how general models of enzymatic equations can be rewired to account for the complexity in vivo approaches. Our work will notably verify (or not) whether a Michaelis-Menten description of the kinetics remains valid in vivo.
 
The candidate will be first responsible for the construction of engineered strains with fine-tuned or inducible expression of CtrE (geranylgeranyl pyrophosphate synthase, GGPP synthase) to modulate intracellular concentration of GGPP, substrate of the phytoene synthase in a range consistent with its KM. Then, he/she will be in charge of analyzing the consequences of the heterologous pathway on the yeast physiology through multi-levels characterization of the recombinant strains.
 
Personal Qualifications
 
• A PhD in the fields of molecular biology, genetics or related fields
 
• Solid experience in metabolic engineering, omics approaches, and microbiology are highly desirable.
 
• Skills in yeast metabolism and experience in multi-partners collaborations will be also strongly appreciated.
 
• Ability to lead good oral and written communication skills, engaged and highly motivated.
 
 
 
Candidates please send a letter that describes your scientific interest and research experience, together with your CV, list of publications and the names of three references to Drs. Carole Camarasa (carole.camarasa@inra.fr) and Virginie Galeote (virginie.galeote@inra.fr).
 
 
 
Application deadline: 01/04/2017. Applications will be reviewed on an ongoing basis.
 

Revision as of 10:59, 16 January 2019

Research Associate – Fermentation at Nucelis (posted 16 January 2019)

Description: Nucelis is focused on delivering naturally sourced and sustainable solutions to the personal care, nutrition and flavor and fragrance markets. Nucelis’ business model is to work with partners to apply our Rapid Trait Development System RTDS™ a suite of proprietary, non-GMO precision gene editing technologies, coupled with extensive fermentation and downstream process development expertise to improve the economics of manufacture of microbial fermentation products.

Position Overview: Nucelis Inc. is looking for an experienced Fermentation Research Associate to join our fermentation process development team. This person will play a hands-on roll among operating our lab and pilot scale fermentations, collecting and processing samples, operating analytical equipment, preparing fermentation experiment documents, and participating in data analysis and process development/improvement discussions. The job will also include some general lab duties such as stocking/ ordering supplies, washing glassware and media preparation.

How to apply: Please check the website (https://www.nucelis.com/join-our-team.php) for the details.

Senior Research Specialist or Scientist – Strain Development (1 position) at Nucelis (posted 16 January 2019)

Nucelis is a trait development company in San Diego, CA, focused on the construction of commercially useful strains of microorganisms is looking for a Senior Research Specialist or Scientist to assist the R&D team to develop microbial hosts for the production of metabolites.

How to apply: Please check the website (https://www.nucelis.com/join-our-team.php) for the details.

Systems Chemical Biologist at Yumanity Therapeutics (posted 7 December 2018)

Description: Yumanity Therapeutics (http://www.yumanity.com/) is transforming drug discovery for neurodegenerative diseases caused by protein misfolding. Even though an estimated 50 million people worldwide suffer from diseases affecting the brain and central nervous system, there are no approved disease-modifying therapies or cures. Yumanity is working to identify and develop new, disease-modifying therapies that address illnesses such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). The company’s approach concentrates on correcting the cellular pathologies driven by misfolded proteins, the altered biology or phenotypes driving these diseases.

Position Overview: The systems chemical biologist will work as an integral part of the target identification team, which uses large-scale forward and reverse genetic approaches to reveal the cellular targets of compounds discovered from phenotypic screens. The position reports to the target identification team lead, and will interact across all Yumanity’s core platforms, including chemistry, yeast screening, and mammalian validation. The successful candidate will become a key individual contributor in a dynamic and multidisciplinary environment. They will demonstrate a respect for others and be highly effective in a team.

For more information on this position, please visit the Yumanity careers page (http://www.yumanity.com/careers/). If you would like to apply, please submit your CV with the "Systems Chemical Biologist" in the subject line to careers@yumanity.com.

Postdoctoral Researcher or Research Scientist Position (1 position) in the Boone Team (RIKEN, Japan) (posted 7 December 2018)

A Postdoctoral Researcher or Research Scientist position is available in Dr. Charles Boone’s laboratory at RIKEN (http://www.riken.jp/en/research/labs/csrs/mol_ligand_targ). We are seeking a highly motivated candidate with strong expertise in yeast genetics/molecular biology and human cell culture experiments. The candidate will develop innovative techniques based on genetic networks in yeast and human cells that leads to quick and accurate detection of the ligand-target interactions.

How to apply: Please check the website (http://www.riken.jp/en/careers/researchers/20181129_5/) for the details.

Postdoctoral Position in Yeast Molecular Biology (posted 5 September 2018)

A NIH-funded postdoctoral position is available in the laboratory of Dr. David Kadosh in the Department of Microbiology, Immunology & Molecular Genetics at the University of Texas Health Science Center at San Antonio. Research will use cutting-edge techniques to study molecular mechanisms that control gene expression, morphology, virulence and virulence-related properties in response to host environmental cues in the yeast Candida albicans, a major human fungal pathogen. For additional details and previous publications, please see https://wp.uthscsa.edu/mimg/team-member/david-kadosh-ph-d/.

Highly motivated individuals with previous experience and a strong track record in molecular biology, genomics, cell biology, genetics, bioinformatics and/or protein chemistry are especially encouraged to apply. Previous experience in fungal pathogenesis is not necessarily required. Please send a cover letter outlining your research interests, CV, and contact information for three references to David Kadosh (kadosh@uthscsa.edu).

Many opportunities are available for collaboration with both basic and clinical researchers at the large and internationally recognized San Antonio Center for Medical Mycology (see http://www.sacmm.org/).

The successful applicant will receive equivalent to NIH-level salary and full benefits. Located in south central Texas, near both Austin and the Texas Hill Country, San Antonio is one of the lowest cost-of-living major metropolitan areas in the U.S.

All postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Employment Opportunity/Affirmative Action Employer.


The Kupiec lab is recruiting PhD students and post-docs (posted 2 July 2018)

Description: PhD positions and post-doctoral research positions are available in Prof. Martin Kupiec’s laboratory at Tel Aviv University (https://mkyeastlab.wixsite.com/mklab). We work with yeast (S. cerevisiae and S. pombe) exploring the role of Elg1 and other proteins in genome stability maintenance and telomere biology. Additional projects include exploring the interphase between DNA replication, chromatin modifications, sister-chromatid cohesion and DNA repair.

We are seeking highly motivated candidates with expertise in molecular biology and genetics. Experience in yeast genetics is desirable, but not a requirement. Independence, communication and interpersonal skills are valued in order to work in a young, dynamic, diverse, and collaborative environment. We are an international team, and research is carried out in English.

How to apply: Prospective candidates should submit a cover letter describing their research experience, scientific interest, career goals, and motivation to apply for this position. Please include an updated CV and the contact information of at least two references. Questions should be directed to Prof. Martin Kupiec at martin@post.tau.ac.il.