Positions in yeast labs

Postdoc Opening - Autophagy of lipid droplets in YEAST (posted 29 August 2017)

Postdoctoral project: Autophagy of lipid droplets in YEAST

Academic institution: University of California, San Diego

Academic division: Division of Biological Sciences

Academic unit: Section of Molecular Biology

Description: Applications are invited for a postdoctoral position in the group of Taras Nazarko studying mechanisms of lipophagy, the selective autophagy of lipid droplets (LDs). Lipophagy is accomplished by delivery of LDs from the cytosol to the lysosome (or vacuole in yeast). As in other autophagic pathways, the core autophagic machinery forms the autophagic isolation membrane that sequesters the LD from the cytosol. However, how this autophagic membrane recognizes the LD after lipophagy induction is unknown. Also, it is not clear how lipophagy is kept in check the rest of the time. Therefore, lipophagy selectivity and regulation are the key gaps in our understanding of this pathway. A postdoctoral scholar will develop a project in one of these areas. Mechanistic understanding in these areas is critical for the precise control of lipophagy in humans for the prevention and treatment of various lipid accumulation diseases, like atherosclerosis and obesity. Initial appointment is for 1 year with possible extension for up to 5 years of overall postdoctoral training. Salary is commensurate with experience (http://postdoc.ucsd.edu/appointment-guidelines/).

Applicant requirements: The successful applicants will have a recent PhD in biochemistry, genetics, molecular or cell biology and a strong background in YEAST genetics, protein biochemistry and fluorescence microscopy. Expertise with mammalian cells or zebrafish model is a plus but not essential. Preference will be given to candidates with experience in autophagy pathway or with LDs.

How to apply: Please send your cover letter, CV and contact information of 3 references to Taras Nazarko, tnazarko@ucsd.edu

Postdoc Position in Non-coding Transcription in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)

Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is seeking a postdoc commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is for 2 years with the possibility of extension. A Hallas-Møller Investigator Award to Sebastian Marquardt funds the position. http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark.

Project description The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . We are looking for a postdoc to work on two lab focus areas within this field:

- Divergent lncRNA Transcription (1)
- Functional Consequences of Non-Coding Transcription (2, 3)

The position builds on unpublished data of the lab. We have identified novel factors controlling transcription of non-coding sequences in budding yeast. You will determine the genome-wide effect of these factors by suitable cutting-edge transcriptomics techniques. You will help to elucidate the molecular mechanisms that are required for divergent non-coding transcription from gene promoters. We use the knowledge of molecular mechanisms to study the functional roles of non-coding transcription in yeast and plants.

We are seeking an enthusiastic candidate familiar with high-throughput approaches, ideally with topically relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and application requirements:

http://jobportal.ku.dk/alle-opslag/?show=904563

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014 (2) Marquardt et al. Mol Cell. 2014 (3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors

Ph.D. Fellow in Non-coding Transcription at University of Copenhagen, Denmark (posted April 25, 2017)

Project description Copenhagen Plant Science Centre (CPSC) at the University of Copenhagen is offering a 3-year Ph.D.-fellowship commencing 1st September 2017 or as soon as possible thereafter. CPSC is a new initiative to promote excellent training opportunities in a modern research environment in the heart of Copenhagen. The position is funded by a Hallas-Møller Investigator Award to Sebastian Marquardt. http://novonordiskfonden.dk/en/content/hallas-m%C3%B8ller-scholarship-denmark

The Marquardt lab is interested in the functional significance of abundant yet mysterious non-coding sequences present in genomes. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/ . Our preliminary data support a Ph.D. position in any of these three focus areas within non-coding transcription research:

- Divergent lncRNA Transcription (1)
- Functional Consequences of Non-Coding Transcription (2, 3)
- Transcription Kinetics in Environmental Interactions (4)

Please specify in your Cover Letter what attracts you for a Ph. D. in any of these focus areas. Our lab employs cutting edge budding yeast technology to identify the molecular mechanisms controlling transcription of non-coding sequences. The knowledge of non-coding transcription mechanisms helps us to study the functional roles of non-coding transcription. For example, we disrupt non-coding transcription in Arabidopsis to identify roles of non-coding transcription in plant environmental responses. http://cpsc.ku.dk/meet-the-scientists-page/sebastian-marquardts-group/

A successful candidate will be enthusiastic about the general research area, ideally with relevant research background. Please apply via the Copenhagen University job portal, where you can also find further information and requirements: http://jobportal.ku.dk/alle-opslag/?show=904540

Deadline: 15th June 2017.

(1) Marquardt et al. Cell. 2014 (2) Marquardt et al. Mol Cell. 2014 (3) *Liu, *Marquardt, et al. Science. 2010 * Joint first authors (4) Hazelbaker, Marquardt, et al. Mol Cell. 2013

12 PhD in yeast biotechnology. Europe.

12 PhD opportunities in YEAST Biotechnology in a European Network called YEASTDOC https://yeastdoc.eu/recruitment/ are available. This is a high quality programmes that deliver comprehensive training in many aspects of yeast biotechnology – as well as an exciting research project that includes interaction with industry partners.

Applicants from any nationality anywhere in the world are eligible to apply and the application deadline is November 13th.

Application deadline: 01/04/2017. Applications will be reviewed on an ongoing basis.