YNL307C
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| Systematic name | YNL307C |
| Gene name | MCK1 |
| Aliases | CMS1, YPK1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:57573..56446 |
| Primary SGDID | S000005251 |
Description of YNL307C: Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family[1][2][3][4]
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References
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- Jump up ↑ Lim MY, et al. (1993) Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. J Biol Chem 268(28):21155-64 SGD PMID 8407952
- Jump up ↑ McQueen J, et al. (2012) The Mck1 GSK-3 kinase inhibits the activity of Clb2-Cdk1 post-nuclear division. Cell Cycle 11(18) SGD PMID 22918234
- Jump up ↑ Neigeborn L and Mitchell AP (1991) The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression. Genes Dev 5(4):533-48 SGD PMID 2010083
- Jump up ↑ Shero JH and Hieter P (1991) A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1). Genes Dev 5(4):549-60 SGD PMID 2010084
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