YNL072W
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| Systematic name | YNL072W |
| Gene name | RNH201 |
| Aliases | RNH35 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIV:490317..491240 |
| Primary SGDID | S000005016 |
Description of YNL072W: Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome[1][2][3][4]
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References
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- ↑ Crow YJ, et al. (2006) Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet 38(8):910-6 SGD PMID 16845400
- ↑ Frank P, et al. (1998) Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII. FEBS Lett 421(1):23-6 SGD PMID 9462832
- ↑ Nick McElhinny SA, et al. (2010) Genome instability due to ribonucleotide incorporation into DNA. Nat Chem Biol 6(10):774-81 SGD PMID 20729855
- ↑ Qiu J, et al. (1999) Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol 19(12):8361-71 SGD PMID 10567561
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