YML030W
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| Systematic name | YML030W |
| Gene name | RCF1 |
| Aliases | AIM31 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:216435..216914 |
| Primary SGDID | S000004492 |
Description of YML030W: Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast[1][2][3][4]
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References
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- ↑ Chen YC, et al. (2012) Identification of a protein mediating respiratory supercomplex stability. Cell Metab 15(3):348-60 SGD PMID 22405070
- ↑ Helbig AO, et al. (2009) A three-way proteomics strategy allows differential analysis of yeast mitochondrial membrane protein complexes under anaerobic and aerobic conditions. Proteomics 9(20):4787-98 SGD PMID 19750512
- ↑ Strogolova V, et al. (2012) Rcf1 and Rcf2, members of the hypoxia induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol Cell Biol () SGD PMID 22310663
- ↑ Vukotic M, et al. (2012) Rcf1 Mediates Cytochrome Oxidase Assembly and Respirasome Formation, Revealing Heterogeneity of the Enzyme Complex. Cell Metab () SGD PMID 22342701
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