YKL212W

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Systematic name YKL212W
Gene name SAC1
Aliases RSD1
Feature type ORF, Verified
Coordinates Chr XI:34543..36414
Primary SGDID S000001695


Description of YKL212W: Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance[1][2][3][4]




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References

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  1. Guo S, et al. (1999) SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J Biol Chem 274(19):12990-5 SGD PMID 10224048
  2. Hughes WE, et al. (2000) SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J Biol Chem 275(2):801-8 SGD PMID 10625610
  3. Schorr M, et al. (2001) The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase. Curr Biol 11(18):1421-6 SGD PMID 11566100
  4. Whitters EA, et al. (1993) SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. J Cell Biol 122(1):79-94 SGD PMID 8314848

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