YKL114C
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| Systematic name | YKL114C |
| Gene name | APN1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:224455..223352 |
| Primary SGDID | S000001597 |
Description of YKL114C: Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine[1][2][3]
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Community Commentary
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The apn1::kanmx4 homozygous diploid mutant from the BY4743 deletion mutant collection displays a growth defect unrelated to the apn1::kanmx4 marker. The haploid BY4742 apn1 deletion mutant also displays this growth defect, suggesting an unidentified semi-dominant mutation arose during construction of this strain. Reconstruction of apn1::kanmx4 in by4741 or by4742 did not recapitulate this growth defect. Literature on the apn1 mutation confirms that apn1 deletion does not normally confer a growth defect in standard (YPD, SD) medium.
Colin MacDiarmid, personal communication.
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References
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- ↑ Ishchenko AA, et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol Cell Biol 25(15):6380-90 SGD PMID 16024777
- ↑ Popoff SC, et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc Natl Acad Sci U S A 87(11):4193-7 SGD PMID 1693433
- ↑ Ramotar D, et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol Cell Biol 11(9):4537-44 SGD PMID 1715020
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