YJL141C
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| Systematic name | YJL141C |
| Gene name | YAK1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr X:150390..147967 |
| Primary SGDID | S000003677 |
Description of YJL141C: Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose[1][2][3][4][5][6]
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References
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- ↑ Garrett S, et al. (1991) The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle. Mol Cell Biol 11(8):4045-52 SGD PMID 2072907
- ↑ Kassis S, et al. (2000) Saccharomyces cerevisiae Yak1p protein kinase autophosphorylates on tyrosine residues and phosphorylates myelin basic protein on a C-terminal serine residue. Biochem J 348 Pt 2():263-72 SGD PMID 10816418
- ↑ Lee P, et al. (2008) Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4. Mol Microbiol 70(4):882-95 SGD PMID 18793336
- ↑ Lee P, et al. (2011) Regulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding. Mol Microbiol 79(3):633-46 SGD PMID 21255108
- ↑ Martin DE, et al. (2004) TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell 119(7):969-79 SGD PMID 15620355
- ↑ Moriya H, et al. (2001) Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal. Genes Dev 15(10):1217-28 SGD PMID 11358866
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