YIL143C
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| Systematic name | YIL143C |
| Gene name | SSL2 |
| Aliases | LOM3, RAD25 |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:83041..80510 |
| Primary SGDID | S000001405 |
Description of YIL143C: Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3[1][2][3][4]
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References
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- ↑ Feaver WJ, et al. (1993) Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair. Cell 75(7):1379-87 SGD PMID 8269516
- ↑ Goel S, et al. (2011) The mechanism of start site selection by RNA polymerase II: interplay between TFIIB and the Ssl2/XPB helicase subunit of TFIIH. J Biol Chem () SGD PMID 22081613
- ↑ Svejstrup JQ, et al. (1995) Different forms of TFIIH for transcription and DNA repair: holo-TFIIH and a nucleotide excision repairosome. Cell 80(1):21-8 SGD PMID 7813015
- ↑ Sweder KS and Hanawalt PC (1994) The COOH terminus of suppressor of stem loop (SSL2/RAD25) in yeast is essential for overall genomic excision repair and transcription-coupled repair. J Biol Chem 269(3):1852-7 SGD PMID 8294433
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