YIL061C
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| Systematic name | YIL061C |
| Gene name | SNP1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:245559..244657 |
| Primary SGDID | S000001323 |
Description of YIL061C: Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein[1][2][3][4][5][6]
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Community Commentary
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Interactions
Two Hybrid
Two Hybrid interaction with NAM7
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [7] [8]
Two Hybrid interaction with Prp8
Prp8 interacts with the U1snRNP protein Snp1 [9] [10]
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References
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- Jump up ↑ Chen YC, et al. (2010) Protein Arginine Methylation Facilitates Cotranscriptional Recruitment of Pre-mRNA Splicing Factors. Mol Cell Biol 30(21):5245-56 SGD PMID 20823272
- Jump up ↑ Gunderson SI, et al. (1998) U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell 1(2):255-64 SGD PMID 9659922
- Jump up ↑ Hilleren PJ, et al. (1995) The amino-terminal domain of yeast U1-70K is necessary and sufficient for function. Mol Cell Biol 15(11):6341-50 SGD PMID 7565787
- Jump up ↑ Kao HY and Siliciano PG (1992) The yeast homolog of the U1 snRNP protein 70K is encoded by the SNP1 gene. Nucleic Acids Res 20(15):4009-13 SGD PMID 1387202
- Jump up ↑ Neubauer G, et al. (1997) Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proc Natl Acad Sci U S A 94(2):385-90 SGD PMID 9012791
- Jump up ↑ Smith V and Barrell BG (1991) Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. EMBO J 10(9):2627-34 SGD PMID 1714384
- Jump up ↑ He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
- Jump up ↑ submitted by Jurgen Wittmann on 2003-04-30
- Jump up ↑ Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15 SGD PMID 11425851
- Jump up ↑ submitted by Richard Grainger on 2003-04-11
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