YGL178W
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| Systematic name | YGL178W |
| Gene name | MPT5 |
| Aliases | HTR1, PUF5, UTH4 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:167352..170571 |
| Primary SGDID | S000003146 |
Description of YGL178W: mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity[1][2][3][4][5][6][7][8][9]
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References
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- ↑ Chen T and Kurjan J (1997) Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17(6):3429-39 SGD PMID 9154842
- ↑ Cridge AG, et al. (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res 38(22):8039-50 SGD PMID 20705650
- ↑ Gerber AP, et al. (2004) Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol 2(3):E79 SGD PMID 15024427
- ↑ Goldstrohm AC, et al. (2006) PUF proteins bind Pop2p to regulate messenger RNAs. Nat Struct Mol Biol 13(6):533-9 SGD PMID 16715093
- ↑ Kaeberlein M and Guarente L (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95 SGD PMID 11805047
- ↑ Kennedy BK, et al. (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89(3):381-91 SGD PMID 9150138
- ↑ Stewart MS, et al. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway. Eukaryot Cell 6(2):262-70 SGD PMID 17172436
- ↑ Tadauchi T, et al. (2001) Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J 20(3):552-61 SGD PMID 11157761
- ↑ Traven A, et al. (2010) The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. PLoS One 5(5):e10651 SGD PMID 20498834
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