YDR470C
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| Systematic name | YDR470C |
| Gene name | UGO1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1401214..1399706 |
| Primary SGDID | S000002878 |
Description of YDR470C: Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter[1][2][3][4][5][6][7]
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References
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- ↑ Anton F, et al. (2011) Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci 124(Pt 7):1126-35 SGD PMID 21385840
- ↑ Becker T, et al. (2011) The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol 194(3):387-95 SGD PMID 21825073
- ↑ Coonrod EM, et al. (2007) Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Traffic 8(5):500-11 SGD PMID 17451553
- ↑ Hoppins S, et al. (2009) Mitochondrial outer and inner membrane fusion requires a modified carrier protein. J Cell Biol 184(4):569-81 SGD PMID 19237599
- ↑ Papic D, et al. (2011) Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. J Cell Biol 194(3):397-405 SGD PMID 21825074
- ↑ Sesaki H and Jensen RE (2001) UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol 152(6):1123-34 SGD PMID 11257114
- ↑ Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 SGD PMID 15087460
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