YDR346C
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| Systematic name | YDR346C |
| Gene name | SVF1 |
| Aliases | SGI1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1168659..1167214 |
| Primary SGDID | S000002754 |
Description of YDR346C: Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance[1][2]
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Contents
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Alleles, Strains, and Phenotypes
Complete Deletion
Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Phenotype(s): Loss of function (Null), Temperature(Heat) Sensitive
Mutant shows decreased growth in glycerol and decreased ability to undergo diauxic shift. These phenotypes are corrected by expression of Bcl-xL. (Conversely, YDR346C has anti-apoptotic activity when expressed in mammalian cells.) Authors have named the gene SVF1, and found homology only to other fungal genes. They suggest that SVF1 may represent an as yet unknown family of genes responsible for adaptation to cellular stress. [2] [3]
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References
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- ↑ Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 SGD PMID 20850176
- ↑ 2.0 2.1 Vander Heiden MG, et al. (2002) Bcl-x(L) complements Saccharomyces cerevisiae genes that facilitate the switch from glycolytic to oxidative metabolism. J Biol Chem 277(47):44870-6
SGD PMID 12244097 Cite error: Invalid
<ref>tag; name "S000071715" defined multiple times with different content - ↑ submitted by Matthew Brauer on 2003-08-28
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References
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