YDL017W
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| Systematic name | YDL017W |
| Gene name | CDC7 |
| Aliases | LSD6, SAS1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:424209..425732 |
| Primary SGDID | S000002175 |
Description of YDL017W: DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p[1][2][3][4][5]
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References
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- ↑ Bell SP and Dutta A (2002) DNA replication in eukaryotic cells. Annu Rev Biochem 71():333-74 SGD PMID 12045100
- ↑ Lo HC, et al. (2011) Cdc7-Dbf4 is a gene-specific regulator of meiotic gene expression in yeast. Mol Cell Biol () SGD PMID 22106412
- ↑ Matos J, et al. (2008) Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I. Cell 135(4):662-78 SGD PMID 19013276
- ↑ Valentin G, et al. (2006) Dual role of the Cdc7-regulatory protein Dbf4 during yeast meiosis. J Biol Chem 281(5):2828-34 SGD PMID 16319063
- ↑ Wan L, et al. (2006) Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics 174(4):1767-74 SGD PMID 17057233
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