YCR034W
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| Systematic name | YCR034W |
| Gene name | FEN1 |
| Aliases | ELO2, GNS1, VBM2 |
| Feature type | ORF, Verified |
| Coordinates | Chr III:190592..191635 |
| Primary SGDID | S000000630 |
Description of YCR034W: Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway[1][2][3][4]
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References
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- Jump up ↑ Abe M, et al. (2001) Yeast 1,3-beta-glucan synthase activity is inhibited by phytosphingosine localized to the endoplasmic reticulum. J Biol Chem 276(29):26923-30 SGD PMID 11337502
- Jump up ↑ Chung JH, et al. (2003) Sphingolipid requirement for generation of a functional v1 component of the vacuolar ATPase. J Biol Chem 278(31):28872-81 SGD PMID 12746460
- Jump up ↑ David D, et al. (1998) Involvement of long chain fatty acid elongation in the trafficking of secretory vesicles in yeast. J Cell Biol 143(5):1167-82 SGD PMID 9832547
- Jump up ↑ Oh CS, et al. (1997) ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J Biol Chem 272(28):17376-84 SGD PMID 9211877
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