YBL039C
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| Systematic name | YBL039C |
| Gene name | URA7 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:145728..143989 |
| Primary SGDID | S000000135 |
Description of YBL039C: Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; URA7 has a paralog, URA8, that arose from the whole genome duplication[1][2][3][4][5][6][7]
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References
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- ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
- ↑ McDonough VM, et al. (1995) Regulation of phospholipid biosynthesis in Saccharomyces cerevisiae by CTP. J Biol Chem 270(32):18774-80 SGD PMID 7642527
- ↑ Nadkarni AK, et al. (1995) Differential biochemical regulation of the URA7- and URA8-encoded CTP synthetases from Saccharomyces cerevisiae. J Biol Chem 270(42):24982-8 SGD PMID 7559626
- ↑ Ostrander DB, et al. (1998) Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae. J Biol Chem 273(30):18992-9001 SGD PMID 9668079
- ↑ Ozier-Kalogeropoulos O, et al. (1991) Cloning, sequencing and characterization of the Saccharomyces cerevisiae URA7 gene encoding CTP synthetase. Mol Gen Genet 231(1):7-16 SGD PMID 1753946
- ↑ Ozier-Kalogeropoulos O, et al. (1994) Use of synthetic lethal mutants to clone and characterize a novel CTP synthetase gene in Saccharomyces cerevisiae. Mol Gen Genet 242(4):431-9 SGD PMID 8121398
- ↑ Yang WL, et al. (1994) Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae. Biochemistry 33(35):10785-93 SGD PMID 8075080
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