YBL020W
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| Systematic name | YBL020W |
| Gene name | RFT1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:182401..184125 |
| Primary SGDID | S000000116 |
Description of YBL020W: Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein[1][2][3][4][5]
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References
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- ↑ Frank CG, et al. (2008) Does Rft1 flip an N-glycan lipid precursor? Nature 454(7204):E3-4; discussion E4-5 SGD PMID 18668045
- ↑ Helenius J, et al. (2002) Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein. Nature 415(6870):447-50 SGD PMID 11807558
- ↑ Koerte A, et al. (1995) Suppression of the yeast mutation rft1-1 by human p53. J Biol Chem 270(38):22556-64 SGD PMID 7673248
- ↑ Rush JS, et al. (2009) Suppression of Rft1 Expression Does Not Impair the Transbilayer Movement of Man5GlcNAc2-P-P-Dolichol in Sealed Microsomes from Yeast. J Biol Chem 284(30):19835-42 SGD PMID 19494107
- ↑ Sanyal S, et al. (2008) Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Biochemistry 47(30):7937-46 SGD PMID 18597486
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