YBR069C

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Systematic name YBR069C
Gene name TAT1
Aliases TAP1, VAP1
Feature type ORF, Verified
Coordinates Chr II:378430..376571
Primary SGDID S000000273


Description of YBR069C: Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance[1][2][3][4][5]




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References

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  1. Jump up Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82 SGD PMID 12709439
  2. Jump up Bajmoczi M, et al. (1998) TAT1 encodes a low-affinity histidine transporter in Saccharomyces cerevisiae. Biochem Biophys Res Commun 243(1):205-9 SGD PMID 9473505
  3. Jump up Schmidt A, et al. (1994) Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake. Mol Cell Biol 14(10):6597-606 SGD PMID 7523855
  4. Jump up Regenberg B, et al. (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28 SGD PMID 10654085
  5. Jump up Heitman J, et al. (1993) The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. Mol Cell Biol 13(8):5010-9 SGD PMID 7687745

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