YOR038C
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| Systematic name | YOR038C | |
| Gene name | HIR2 | |
| Aliases | SPT1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr XV:405388..402761 | |
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Description of YOR038C: Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p[1][2][3][4][5][6]
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References
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- ↑ Sharp JA, et al. (2001) Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing. Curr Biol 11(7):463-73 SGD PMID 11412995
- ↑ Spector MS, et al. (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52 SGD PMID 9001207
- ↑ Sherwood PW, et al. (1993) Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(1):28-38 SGD PMID 8417331
- ↑ Dimova D, et al. (1999) A role for transcriptional repressors in targeting the yeast Swi/Snf complex. Mol Cell 4(1):75-83 SGD PMID 10445029
- ↑ Kaufman PD, et al. (1998) Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I. Mol Cell Biol 18(8):4793-806 SGD PMID 9671489
- ↑ DeSilva H, et al. (1998) Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor. Genetics 148(2):657-67 SGD PMID 9504914
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