YOL027C

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Systematic name YOL027C
Gene name MDM38
Aliases MKH1
Feature type ORF, Verified
Coordinates Chr XV:273725..272004
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Description of YOL027C: Mitochondrial inner membrane protein, required for K+/H+ exchange and for normal mitochondrial morphology and inheritance; associates with mitochondrial ribosomes; human ortholog Letm1 is implicated in Wolf-Hirschhorn syndrome[1][2][3][4]



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References

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  1. Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 SGD PMID 16476776
  2. Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 SGD PMID 15904662
  3. Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 SGD PMID 15138253
  4. Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53 SGD PMID 11907266

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