YLR450W
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| Systematic name | YLR450W | |
| Gene name | HMG2 | |
| Aliases | ||
| Feature type | ORF, Verified | |
| Coordinates | Chr XII:1032624..1035761 | |
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Description of YLR450W: One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks[1][2][3][4]
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References
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- ↑ Koning AJ, et al. (1996) Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell 7(5):769-89 SGD PMID 8744950
- ↑ Wright R, et al. (1988) Increased amounts of HMG-CoA reductase induce "karmellae": a proliferation of stacked membrane pairs surrounding the yeast nucleus. J Cell Biol 107(1):101-14 SGD PMID 3292536
- ↑ Basson ME, et al. (1986) Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A 83(15):5563-7 SGD PMID 3526336
- ↑ Parks LW, et al. (1995) Biochemical and physiological effects of sterol alterations in yeast--a review. Lipids 30(3):227-30 SGD PMID 7791530
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