YGR184C
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| Systematic name | YGR184C | |
| Gene name | UBR1 | |
| Aliases | PTR1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr VII:865758..859906 | |
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Description of YGR184C: Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome[1][2][3][4][5]
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References
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- ↑ Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30():405-39 SGD PMID 8982460
- ↑ Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 SGD PMID 10688918
- ↑ Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 SGD PMID 2065660
- ↑ Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 SGD PMID 2209542
- ↑ Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 SGD PMID 1651502
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