YDR110W

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Systematic name YDR110W
Gene name FOB1
Aliases HRM1
Feature type ORF, Verified
Coordinates Chr IV:676099..677799
Primary SGDID S000002517


Description of YDR110W: Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases[1][2][3][4]




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References

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  1. Kobayashi T (2003) The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork. Mol Cell Biol 23(24):9178-88 SGD PMID 14645529
  2. Dlakic M (2002) A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases. Protein Sci 11(5):1274-7 SGD PMID 11967383
  3. Kobayashi T and Horiuchi T (1996) A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities. Genes Cells 1(5):465-74 SGD PMID 9078378
  4. Defossez PA, et al. (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3(4):447-55 SGD PMID 10230397

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