YDR397C
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| Systematic name | YDR397C | |
| Gene name | NCB2 | |
| Aliases | YDR1 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IV:1266890..1266358 | |
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Description of YDR397C: Beta subunit of the NC2 dimeric histone-fold complex; represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB; homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2)[1][2]
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References
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- Jump up ↑ Gadbois EL, et al. (1997) Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Proc Natl Acad Sci U S A 94(7):3145-50 SGD PMID 9096360
- Jump up ↑ Lemaire M, et al. (2000) The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. Mol Microbiol 36(1):163-73 SGD PMID 10760173
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