YDR392W

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Systematic name YDR392W
Gene name SPT3
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1258688..1259701
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Description of YDR392W: Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters[1][2][3]



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References

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  1. Grant PA, et al. (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11(13):1640-50 SGD PMID 9224714
  2. Eisenmann DM, et al. (1992) SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae. Genes Dev 6(7):1319-31 SGD PMID 1628834
  3. Belotserkovskaya R, et al. (2000) Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters. Mol Cell Biol 20(2):634-47 SGD PMID 10611242

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