YPL153C
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| Systematic name | YPL153C |
| Gene name | RAD53 |
| Aliases | LSD1, MEC2, SPK1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:264191..261726 |
Description of YPL153C: Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication[1][2][3]
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References
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- ↑ Dohrmann PR and Sclafani RA (2006) Novel Role for Checkpoint Rad53 Protein Kinase in the Initiation of Chromosomal DNA Replication in Saccharomyces cerevisiae. Genetics 174(1):87-99 SGD PMID 16816422
- ↑ Toh GW and Lowndes NF (2003) Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem Soc Trans 31(Pt 1):242-6 SGD PMID 12546694
- ↑ Schwartz MF, et al. (2002) Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell 9(5):1055-65 SGD PMID 12049741
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