YOR098C

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Systematic name YOR098C
Gene name NUP1
Aliases
Feature type ORF, Verified
Coordinates Chr XV:511179..507949


Description of YOR098C: Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate[1][2][3]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]




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References

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  1. Gilchrist D, et al. (2002) Accelerating the rate of disassembly of karyopherin.cargo complexes. J Biol Chem 277(20):18161-72 SGD PMID 11867631
  2. Davis LI and Fink GR (1990) The NUP1 gene encodes an essential component of the yeast nuclear pore complex. Cell 61(6):965-78 SGD PMID 2190694
  3. Bogerd AM, et al. (1994) nup1 mutants exhibit pleiotropic defects in nuclear pore complex function. J Cell Biol 127(2):319-32 SGD PMID 7929578
  4. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  5. submitted by Jeff Ubersax on 2004-01-29

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