YNL298W

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Systematic name YNL298W
Gene name CLA4
Aliases ERC10
Feature type ORF, Verified
Coordinates Chr XIV:68915..71443


Description of YNL298W: Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p[1][2][3][4]




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References

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  1. Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 SGD PMID 14993234
  2. Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 SGD PMID 14517318
  3. Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 SGD PMID 7649470
  4. Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 SGD PMID 9271384

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