YLR332W
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| Systematic name | YLR332W |
| Gene name | MID2 |
| Aliases | KAI1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:790676..791806 |
| Primary SGDID | S000004324 |
Description of YLR332W: O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p[1][2]
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Community Commentary
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Transmembrane Domain GxxxG
The transmembrane domain of Mid2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iviGcvvG. The presence of GxxxG motifs [3] strongly indicates that Mid2p dimerisation.
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References
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- ↑ Green R, et al. (2003) A synthetic analysis of the Saccharomyces cerevisiae stress sensor Mid2p, and identification of a Mid2p-interacting protein, Zeo1p, that modulates the PKC1-MPK1 cell integrity pathway. Microbiology 149(Pt 9):2487-99 SGD PMID 12949174
- ↑ Philip B and Levin DE (2001) Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1. Mol Cell Biol 21(1):271-80 SGD PMID 11113201
- ↑ Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242
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