YDL160C-A
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Systematic name | YDL160C-A |
Gene name | MHF2 |
Aliases | |
Feature type | ORF, Verified |
Coordinates | Chr IV:169608..169366 |
Primary SGDID | S000028520 |
Description of YDL160C-A: Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2[1][2][3]
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References
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- ↑ Schleiffer A, et al. (2012) CENP-T proteins are conserved centromere receptors of the Ndc80 complex. Nat Cell Biol 14(6):604-13 SGD PMID 22561346
- ↑ Yan Z, et al. (2010) A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell 37(6):865-78 SGD PMID 20347428
- ↑ Yang H, et al. (2012) Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer. Structure 20(2):364-70 SGD PMID 22325783
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