YLR113W
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| Systematic name | YLR113W |
| Gene name | HOG1 |
| Aliases | SSK3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:371620..372927 |
| Primary SGDID | S000004103 |
Description of YLR113W: Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p[1][2][3][4][5][6]
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References
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- ↑ Alepuz PM, et al. (2003) Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II. EMBO J 22(10):2433-42 SGD PMID 12743037
- ↑ Brewster JL, et al. (1993) An osmosensing signal transduction pathway in yeast. Science 259(5102):1760-3 SGD PMID 7681220
- ↑ Cook KE and O'Shea EK (2012) Hog1 Controls Global Reallocation of RNA Pol II upon Osmotic Shock in Saccharomyces cerevisiae. G3 (Bethesda) 2(9):1129-36 SGD PMID 22973550
- ↑ Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 SGD PMID 21576396
- ↑ Mattison CP and Ota IM (2000) Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev 14(10):1229-35 SGD PMID 10817757
- ↑ O'Rourke SM and Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49 SGD PMID 12052881
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