YBR278W
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| Systematic name | YBR278W |
| Gene name | DPB3 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr II:760294..760899 |
| Primary SGDID | S000000482 |
Description of YBR278W: Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle[1][2][3][4]
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References
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- ↑ Aksenova A, et al. (2010) Mismatch Repair-Independent Increase in Spontaneous Mutagenesis in Yeast Lacking Non-Essential Subunits of DNA Polymerase epsilon. PLoS Genet 6(11):e1001209 SGD PMID 21124948
- ↑ Araki H, et al. (1991) Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. Nucleic Acids Res 19(18):4867-72 SGD PMID 1923754
- ↑ Iida T and Araki H (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27 SGD PMID 14673157
- ↑ Li Y, et al. (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52 SGD PMID 10801849
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