YDR103W
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| Systematic name | YDR103W | |
| Gene name | STE5 | |
| Aliases | HMD3, NUL3 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr IV:658347..661100 | |
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Description of YDR103W: Pheromone-responsive scaffold protein; shuttles from the nucleus to the plasma membrane and assembles kinases Ste11p, Ste7p, and Fus3p into a specific signaling complex; active oligomeric form interacts with Ste4p-Ste18p complex[1][2][3][4]
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References
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- ↑ Wang Y and Elion EA (2003) Nuclear export and plasma membrane recruitment of the Ste5 scaffold are coordinated with oligomerization and association with signal transduction components. Mol Biol Cell 14(6):2543-58 SGD PMID 12808050
- ↑ Kranz JE, et al. (1994) The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Genes Dev 8(3):313-27 SGD PMID 8314085
- ↑ Printen JA and Sprague GF Jr (1994) Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138(3):609-19 SGD PMID 7851759
- ↑ Choi KY, et al. (1999) Characterization of Fus3 localization: active Fus3 localizes in complexes of varying size and specific activity. Mol Biol Cell 10(5):1553-68 SGD PMID 10233162
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