YML014W
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| Systematic name | YML014W |
| Gene name | TRM9 |
| Aliases | KTI1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XIII:243225..244064 |
| Primary SGDID | S000004476 |
Description of YML014W: tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses[1][2][3][4]
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References
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- Jump up ↑ Jablonowski D, et al. (2006) tRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast. Mol Microbiol 59(2):677-88 SGD PMID 16390459
- Jump up ↑ Kalhor HR and Clarke S (2003) Novel methyltransferase for modified uridine residues at the wobble position of tRNA. Mol Cell Biol 23(24):9283-92 SGD PMID 14645538
- Jump up ↑ Patil A, et al. (2012) Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. RNA Biol 9(7) SGD PMID 22832247
- Jump up ↑ Studte P, et al. (2008) tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Mol Microbiol 69(5):1266-77 SGD PMID 18657261
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