YGL207W

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Systematic name YGL207W
Gene name SPT16
Aliases CDC68, SSF1
Feature type ORF, Verified
Coordinates Chr VII:98973..102080


Description of YGL207W: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure[1][2]




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References

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  1. Belotserkovskaya R, et al. (2003) FACT facilitates transcription-dependent nucleosome alteration. Science 301(5636):1090-3 SGD PMID 12934006
  2. Formosa T, et al. (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71 SGD PMID 12524332

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