YLR403W
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| Systematic name | YLR403W |
| Gene name | SFP1 |
| Aliases | [ISP(+)], [ISP+] |
| Feature type | ORF, Verified |
| Coordinates | Chr XII:925568..927619 |
| Primary SGDID | S000004395 |
Description of YLR403W: Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion[1][2][3][4][5][6][7][8][9][10]
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References
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- ↑ Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9 SGD PMID 9171100
- ↑ Cipollina C, et al. (2005) SFP1 is involved in cell size modulation in respiro-fermentative growth conditions. Yeast 22(5):385-99 SGD PMID 15806610
- ↑ Gordan R, et al. (2009) Distinguishing direct versus indirect transcription factor-DNA interactions. Genome Res 19(11):2090-100 SGD PMID 19652015
- ↑ Jorgensen P, et al. (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400 SGD PMID 12089449
- ↑ Jorgensen P, et al. (2004) A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev 18(20):2491-505 SGD PMID 15466158
- ↑ Lempiainen H, et al. (2009) Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling. Mol Cell 33(6):704-16 SGD PMID 19328065
- ↑ Marion RM, et al. (2004) Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Proc Natl Acad Sci U S A 101(40):14315-22 SGD PMID 15353587
- ↑ Xu Z and Norris D (1998) The SFP1 gene product of Saccharomyces cerevisiae regulates G2/M transitions during the mitotic cell cycle and DNA-damage response. Genetics 150(4):1419-28 SGD PMID 9832520
- ↑ Zeevi D, et al. (2011) Compensation for differences in gene copy number among yeast ribosomal proteins is encoded within their promoters. Genome Res () SGD PMID 22009988
- ↑ Zhu C, et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66 SGD PMID 19158363
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