YDL175C
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| Systematic name | YDL175C |
| Gene name | AIR2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:145518..144484 |
| Primary SGDID | S000002334 |
Description of YDL175C: RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p; has 5 zinc knuckle motifs[1][2][3][4][5]
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References
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- ↑ Holub P, et al. (2012) Air2p is critical for the assembly and RNA-binding of the TRAMP complex and the KOW domain of Mtr4p is crucial for exosome activation. Nucleic Acids Res () SGD PMID 22402490
- ↑ Inoue K, et al. (2000) Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p. J Biol Chem 275(42):32793-9 SGD PMID 10896665
- ↑ LaCava J, et al. (2005) RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. Cell 121(5):713-24 SGD PMID 15935758
- ↑ Vanacova S, et al. (2005) A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol 3(6):e189 SGD PMID 15828860
- ↑ Wyers F, et al. (2005) Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. Cell 121(5):725-37 SGD PMID 15935759
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